Enoch was part of what was used to be known as "The Organization," a crew that dedicated themselves to experiment on extraterrestrial life. In the episode, "A Small Problem," Howell brings Grey Matter to him, not knowing that Enoch did not care about fame and fortune. Howell attempts to fight back for his prize, though he has no luck. In the end, Howell finds his life to be difficult, so he quits his job as an alien hunter. Enoch however, continues his suspicions towards the Tennysons.
In the episode, "Ultimate Weapon," the Tennysons encounter Enoch once again, and his crew is now known as the Forever Knights. They were both after the same artifact: The Mask of Ah Puch, which is the key to the legendary sword of Ekchuah. Unfortunately for him, even though he got to the sword first, he got nothing but 5,000 years of dust.
At his next attempt to obtain the Omnitrix, he decides to kidnap Ben and place him in a sleep, manipulating his dreams using a special machine. With the help of Grandpa Max and Gwen, they were able to free Ben from Enoch's clutches, and instead, give Enoch a taste of his own medicine.